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Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking tapentadol, it is important that your doctor or pharmacist knows:

  • If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
  • If you have liver or kidney problems.
  • If you have prostate or thyroid problems.
  • If you have epilepsy or low blood pressure.
  • If you have a problem with your bile duct.
  • If you are pregnant or breast-feeding.
  • If you have been constipated for more than a week or have an inflammatory bowel problem.
  • If you have ever been dependent on drugs or alcohol.
  • If you have recently had a severe head injury.
  • If you have a condition called myasthenia gravis (a muscle wasting disease).
  • If you have ever had an allergic reaction to this or to any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.


  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the specific brand of tapentadol you have been given, and a full list of possible side-effects from taking it.
  • Take these tablets exactly as your doctor has told you. Your doctor or pharmacist will tell you how many to take and when to take them. Your dose will also be on the label of your pack.
  • You can take the tablets before, during or after your meals.
  • If you have been given prolonged-release tablets (these have 'SR' after the name - for example, Palexia® SR) these are specially formulated to release the medicine slowly to give you a more even painkilling effect. You should swallow these tablets whole - do not chew or crush them.
  • If you forget to take a dose, take it as soon as you remember and then continue as before. Do not take two doses together to make up for a forgotten dose.
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Tapentadol is a strong painkiller which works in two ways. It binds to certain receptors (called opioid receptors) in your brain and spinal cord, and it also regulates the level of a chemical called noradrenaline in your brain. These actions together reduce the pain you feel.

Tapentadol is used to ease pain which cannot be managed with other types of painkillers.
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